109 papers
This study demonstrates that wildfire-emitted particulate matter (WFPM0.1) induces ovarian hyperandrogenism and disrupts female reproductive function in mice by activating the aryl hydrocarbon receptor (AhR) pathway, thereby altering steroidogenic gene expression and testosterone secretion.
The paper introduces KINESIS, a novel nanofabricated platform utilizing valinomycin-coated nanopillars to enable label-free, subcellular-resolution, and chemically specific monitoring of potassium dynamics in human iPSC-derived cardiomyocytes, overcoming the limitations of existing electrophysiological tools for cardiac disease modeling and drug screening.
This study reveals that human prostaglandin reductases PTGR1 and PTGR2 inactivate the antitubercular drug macozinone by catalyzing its reductive dearomatization, a novel host-mediated metabolic pathway that can be inhibited to restore the drug's efficacy.
This pilot study utilized a novel, high-depth plasma proteomics and phosphoproteomics platform on a subset of patients from the STOP trial to identify a comprehensive molecular signature of semaglutide's pleiotropic cardiometabolic effects, revealing thousands of differentially abundant proteins and phosphoproteins that elucidate the drug's underlying pathways and align with imaging biomarkers in patients with type 2 diabetes and atherosclerosis.
This paper introduces a novel, cost-effective, and sensitive fluorescence nested allele-specific (FAS) PCR method for multiplex genotyping of CYP2C19 variants that matches the accuracy of pyrosequencing while overcoming the complexity and expense of current clinical screening protocols.
The study demonstrates that the novel Drp1 inhibitor DRP1i2 effectively protects against doxorubicin-induced cardiotoxicity by preserving cardiac structure and function in both murine and human models, while maintaining or even enhancing anticancer efficacy across various cancer cell lines.
This paper presents a novel diet-induced rat screening model that mimics typical Indian cereal-rich, high-fat dietary patterns to reproducibly generate hypertriglyceridemia-associated fatty liver with minimal inflammation, offering a translationally relevant tool for prioritizing lipid-modulating interventions without proposing a new disease model or evaluating therapeutic efficacy.
This study demonstrates that in hypertensive mice, activating endothelial KCa2.2/2.3 channels with the opener NS13001 reverses erectile dysfunction by inhibiting the ET-1-induced NLRP3 inflammasome activation pathway in corpus cavernosum endothelial cells.
This study demonstrates that while light-activated ion-channel blockers show variable efficacy in human versus mouse brain tissue, a newly developed caged propofol (CaP) robustly suppresses epileptiform activity across species, highlighting the critical need for early human model testing in photopharmacology to develop precision therapies for medically refractory epilepsy.